Urolithin A Found to Rejuvenate Aging Immune Cells in Just 28 Days

GENEVA - A new international study has found that Urolithin A, a compound naturally produced in the human body, can rejuvenate aging immune cells within just 28 days when taken daily at a dose of 1,000 milligrams (7/11/2025).

According to a report by Medical Xpress, researchers discovered that the compound helps shift human immune cells toward a “younger” or naïve-like profile, while improving fatty acid oxidation capacity a key indicator of restored immune cell function.

“Urolithin A appears to enhance mitochondrial health and strengthen energy metabolism in immune cells,” the researchers said as quoted by Medical Xpress. “These findings open the door to nutritional interventions that could help sustain immune health as we age.”

The decline in immune performance due to aging, known as immunosenescence, is a major risk factor for chronic diseases such as diabetes, cancer, and infections. Scientists suggest that this discovery could pave the way for new nutritional or therapeutic approaches to maintain immune resilience in older adults.

However, the team cautioned that this is still early-stage research and not yet ready for clinical recommendation. “Larger and longer-term studies are needed to confirm Urolithin A’s safety and efficacy in broader populations,” the report stated.

Urolithin A is a metabolite derived from polyphenols, found naturally in foods such as pomegranates, nuts, and berries. It has gained scientific attention in recent years for its ability to restore mitochondrial function, delay muscle aging, and now potentially revitalize immune cells.

Health experts note that while Urolithin A supplements are available commercially, consumers should be cautious and seek medical advice before using them as part of a daily regimen.

“We haven’t found a magic pill for longevity yet,” said an immunologist from the Swiss Federal Institute of Technology. “But this study brings us one step closer to understanding how the body regenerates itself at the cellular level.”